Male factor infertility or paternal age are not associated with embryo aneuploidy

Frequency of aneuploidy in sperm from patients with extremely severe male factor infertility.

BACKGROUND A protocol for the chromosomal analysis of sperm samples with a severely reduced number of sperm cells was designed. METHODS A severe male factor condition was the main cause of infertility for 38 couples: 27 were oligoasthenoteratospermic (OAT) and 11 with non-obstructive azoospermia underwent testicular sperm extraction (TESE). A two-round fluorescence in situ hybridization (FISH...

Mutations of Two Major Coagulation Factors Are Not Associated with Male Infertility.

BACKGROUND Thrombophilia-related mutations, such as coagulation factor V Leiden and factor II (G20210A), have been associated with female infertility due to spontaneous abortions during pregnancy. The possible role of mutations of these two factors in male infertility has not been studied to date. MATERIALS AND METHODS A total of 208 unrelated Greek men were investigated, including 108 infert...

P-206: Mov10l1 Gene Polymorphisms Are Probably Associated to Male Infertility in Azoospermic Men with Complete Maturation Arrest

Background: Thousands of genes are involved in spermatogenesis. Alterations in any of these genes could lead to male infertility. Moloney leukemia virus 10-Like 1 (Mov10l1) gene is one of the genes that are expressed specifically in germ cells. Genetic disruption of this gene in mouse stops spermatogenesis during Meiosis I and causes azoospermia. Materials and Methods: In this study, the geneti...

Gene Mutations Associated with Male Infertility

I-6: Azoospermia Factor in Male Infertility

Background The human Y chromosome is essential for human sex determination and male germ cell development and maintenance. In 1996, Vogt et al. identified three recurrently deleted regions in Yq11 termed the azoospermia factor (AZF). The AZF region is subdivided into three non-overlapping sub-regions called AZFa, AZFb and AZFc and microdeletion in these regions is the most important etiology of...